Pneumococcal transformation experiment

Griffith conducted a pneumococcal transformation experiment in 1928. The pathogenic pneumococcal bacteria killed by heating were mixed with non pathogenic bacteria and injected into mice, and it was found that the non pathogenic bacteria transformed into pathogenicity, proving the existence of a "transformation factor". Subsequent experiments further revealed that only DNA can induce non pathogenic bacteria to transform into pathogenicity, and the transformation efficiency is related to DNA purity, confirming that DNA is the "transformation factor" that can trigger bacterial transformation.

The unit is designed for unsupervised public use: controls are recessed or shielded, moving parts are enclosed, and the interface is operable by a child of about six with no instruction. Where a screen is used, the language can be switched without changing the hardware, and the content can be replaced on site.

Griffith's pneumococcal transformation experiment showed that when pathogenic bacteria killed by heating were mixed with non pathogenic bacteria, non pathogenic bacteria could be transformed into pathogenic bacteria, proving the existence of a "transformation factor". Subsequent research has found that DNA is a key factor in this transformation, and the transformation efficiency is related to the purity of DNA. This experiment confirms for the first time the central role of DNA as genetic material.