Same origin repair

When a double strand of DNA breaks, cells will attempt to repair the break. By utilizing this feature, scientists can carry out homologous repair by providing a DNA template that is homologous to the DNA to be repaired, allowing the repaired DNA to complete the repair of double stranded breaks by replicating the homologous template. If there are some "modifications" in the template DNA, that is, changes in the local structure of the template DNA, specific mutations can be introduced into the damaged DNA, allowing the repaired DNA to achieve the expected function.

The unit is designed for unsupervised public use: controls are recessed or shielded, moving parts are enclosed, and the interface is operable by a child of about six with no instruction. Where a screen is used, the language can be switched without changing the hardware, and the content can be replaced on site.

Homologous recombination repair is an important DNA repair mechanism, which can accurately repair double strand breaks by using an undamaged sisters chromatid as a template. This process relies on the high similarity or homology of DNA sequences, ensuring the accurate transmission of genetic information and the stability of the cellular genome. Homologous recombination repair is an important application principle of gene editing.